Genetic Contribution to Alcohol Dependence: Investigation of Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis
- Treutlein, J.
- Frank, J.
- Streit, F.
- Reinbold, C.
- Juraeva, D.
- Degenhardt, F.
- Rietschel, L.
- Witt, S.
- Forstner, A.
- Ridinger, M.
- Strohmaier, J.
- Wodarz, N.
- Dukal, H.
- Foo, J.
- Hoffmann, P.
- Herms, S.
- Heilmann-Heimbach, S.
- Soyka, M.
- Maier, W.
- Gaebel, W.
- Dahmen, N.
- Scherbaum, N.
- Müller-Myhsok, B.
- Lucae, S.
- Ising, M.
- Stickel, F.
- Berg, T.
- Roggenbuck, U.
- Joeckel, K.
- Scholz, H.
- Zimmermann, U.
- Buch, S.
- Sommer, W.
- Spanagel, R.
- Brors, B.
- Cichon, S.
- Mann, K.
- Kiefer, F.
- Hampe, J.
- Rosendahl, J.
- Noethen, M.
- Rietschel, M.
DOIAbstract
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (p(uncorrected) = 1.2 x 10(-6); p(corrected) = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups...
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