Add to ORKGTelomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert. β-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of β-catenin (β-catΔEx3/+) have long telomeres. We show that β-catenin regulates Tert expression through the interaction with Klf4, a core component of the pluripotency transcriptional network. β-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells. We uncover a previously unknown link between the stem cell and oncogenic potential whereby β-catenin regulates T...
Canonical Wnt signaling is repeatedly used during development to control cell fate, and it is often ...
2012-05-04The telomerase reverse transcriptase (TERT) component of telomerase has reverse transcript...
Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem c...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorig...
International audienceThe DNA-binding protein TRF2 is essential for telomere protection and chromoso...
Hepatocellular carcinoma (HCC) is one of the deadliest human cancers. Activating mutations in the te...
Background: A few reports suggested that low levels of Wnt signaling might drive cell reprogramming,...
Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to...
Abstract Background A few reports suggested that low levels of Wnt signaling might drive cell reprog...
In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but how and for ...
<div><p>The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the...
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance...
Canonical Wnt signaling is repeatedly used during development to control cell fate, and it is often ...
2012-05-04The telomerase reverse transcriptase (TERT) component of telomerase has reverse transcript...
Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem c...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and canc...
Stem cells are controlled, in part, by genetic pathways frequently dysregulated during human tumorig...
International audienceThe DNA-binding protein TRF2 is essential for telomere protection and chromoso...
Hepatocellular carcinoma (HCC) is one of the deadliest human cancers. Activating mutations in the te...
Background: A few reports suggested that low levels of Wnt signaling might drive cell reprogramming,...
Telomeres are the terminal structures at the ends of linear chromosomes that represent a solution to...
Abstract Background A few reports suggested that low levels of Wnt signaling might drive cell reprog...
In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but how and for ...
<div><p>The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the...
The canonical Wnt/β-catenin signaling pathway plays a crucial role in the maintenance of the balance...
Canonical Wnt signaling is repeatedly used during development to control cell fate, and it is often ...
2012-05-04The telomerase reverse transcriptase (TERT) component of telomerase has reverse transcript...
Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem c...