Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which have been best characterised in a large pedigree called the KE family. The encoded protein is highly conserved in many vertebrates and is expressed in homologous brain regions required for sensorimotor integration and motor-skill learning, in particular corticostriatal circuits. Independent studies in multiple species suggest that the striatum is a key site of FOXP2 action. Here, we used in vivo recordings in awake-behaving mice to investigate the effects of the KE-family mutation on the function of striatal circuits during motor-skill learning. We uncovered abnormally high ongoing striatal activity in mice carrying an identical mutation to th...
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by im...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
SummaryThe most well-described example of an inherited speech and language disorder is that observed...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequenc...
Mutations in the FOXP2 gene cause a severe neurodevelopmental speech and language disorder. In the K...
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened...
Heterozygous mutations of the Forkhead-box protein 2 (FOXP2) gene in humans cause childhood apraxia ...
The most well-described example of an inherited speech and language disorder is that observed in the...
Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described example...
Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe develop...
In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by im...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
SummaryThe most well-described example of an inherited speech and language disorder is that observed...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Mutations in the human FOXP2 gene cause impaired speech development and linguistic deficits, which h...
Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequenc...
Mutations in the FOXP2 gene cause a severe neurodevelopmental speech and language disorder. In the K...
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened...
Heterozygous mutations of the Forkhead-box protein 2 (FOXP2) gene in humans cause childhood apraxia ...
The most well-described example of an inherited speech and language disorder is that observed in the...
Heterozygous mutations of the human FOXP2 transcription factor gene cause the best-described example...
Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe develop...
In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by im...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
SummaryThe most well-described example of an inherited speech and language disorder is that observed...