The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains
Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, bind...
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolate...
SummaryCrystal structures of H. marismortui large ribosomal subunits containing the mutation G2099A ...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of e...
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of e...
AbstractThe azalide azithromycin and the ketolide ABT-773, which were derived by chemical modificati...
Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatmen...
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macroli...
Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the rib...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolate...
Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, bind...
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolate...
SummaryCrystal structures of H. marismortui large ribosomal subunits containing the mutation G2099A ...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribos...
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of e...
The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of e...
AbstractThe azalide azithromycin and the ketolide ABT-773, which were derived by chemical modificati...
Since their discovery, the macrolide antimicrobials have proved clinically valuable for the treatmen...
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macroli...
Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the rib...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
We characterized the mechanism of action and the drug-binding site of a novel ketolide, CEM-101, whi...
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolate...
Applying kinetics and footprinting analysis, we show that telithromycin, a ketolide antibiotic, bind...
Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolate...
SummaryCrystal structures of H. marismortui large ribosomal subunits containing the mutation G2099A ...
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