Mental retardation affects 2-3% of the population and shows a high heritability.Neurodevelopmental disorders that include pronounced impairment in language and speech skills occur less frequently. For most cases, the molecular basis of mental retardation with or without speech and language disorder is unknown due to the heterogeneity of underlying genetic factors.We have used molecular karyotyping on 1523 patients with mental retardation to detect copy number variations (CNVs) including deletions or duplications. These studies revealed three heterozygous overlapping deletions solely affecting the forkhead box P1 (FOXP1) gene. All three patients had moderate mental retardation and significant language and speech deficits. Since our results a...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Mutations in FOXP1, located at 3p13, have been reported in patients with global developmental delay ...
Mental retardation affects 2-3% of the population and shows a high heritability.Neurodevelopmental d...
Mental retardation affects 2-3% of the population and shows a high heritability. Neurodevelopmental ...
Mental retardation affects 2-3% of the population and shows a high heritability.Neurodevelopmental d...
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have been shown to c...
Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the...
Intellectual disability (ID) is a neurodevelopmental disorder manifesting in children before the age...
BACKGROUND: Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are the first k...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Mutations in FOXP1, located at 3p13, have been reported in patients with global developmental delay ...
Mental retardation affects 2-3% of the population and shows a high heritability.Neurodevelopmental d...
Mental retardation affects 2-3% of the population and shows a high heritability. Neurodevelopmental ...
Mental retardation affects 2-3% of the population and shows a high heritability.Neurodevelopmental d...
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have been shown to c...
Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
FOXP2, the first gene to have been implicated in a developmental communication disorder, offers a un...
Neurodevelopmental disorders that disturb speech and language are highly heritable. Isolation of the...
Intellectual disability (ID) is a neurodevelopmental disorder manifesting in children before the age...
BACKGROUND: Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are the first k...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Childhood syndromes disturbing language development are common and display high degrees of heritabil...
Mutations in FOXP1, located at 3p13, have been reported in patients with global developmental delay ...