Add to ORKGNon-coding DNA segments that are conserved between the human and mouse genomic sequence are good indicators of possible regulatory sequences. Here we report on a systematic approach to delineate such conserved elements from upstream regions of orthologous gene pairs from man and mouse. We focus on orthologous genes in order to maximize our chances to find functionally similar regulatory elements. The identification of conserved elements is effected using the Waterman–Eggert local suboptimal alignment algorithm. We have modified an implementation of this algorithm such that it integrates the determination of statistical significance for the local suboptimal alignments. This has the effect of outputting a dynamically determined number of subo...
Our inability to associate distant regulatory elements with the genes that they regulate has largel...
To broaden our understanding of the evolution of gene regulation mechanisms, we generated occupancy ...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
Non-coding DNA segments that are conserved between the human and mouse genomic sequence are good ind...
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is lik...
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is lik...
We explore several computational approaches to analyzing interspecies genomic sequence alignments, a...
Cross-species DNA sequence comparison is the primary method used to identify functional noncoding el...
Cross-species DNA sequence comparison is the primary method used to identify functional noncoding e...
Background: The accurate detection of genes and the identification of functional regions is still an...
Genome wide disease association analysis using SNPs is being explored as a method for dissecting com...
We address the problem of comparing and characterizing the promoter regions of genes with similar ex...
Our inability to associate distant regulatory elements with the genes that they regulate has largely...
The laboratory mouse is the most widely used mammalian model organism in biomedical research. The 2....
To understanding the interaction network among transcription-regulation elements in human is an imme...
Our inability to associate distant regulatory elements with the genes that they regulate has largel...
To broaden our understanding of the evolution of gene regulation mechanisms, we generated occupancy ...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...
Non-coding DNA segments that are conserved between the human and mouse genomic sequence are good ind...
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is lik...
Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is lik...
We explore several computational approaches to analyzing interspecies genomic sequence alignments, a...
Cross-species DNA sequence comparison is the primary method used to identify functional noncoding el...
Cross-species DNA sequence comparison is the primary method used to identify functional noncoding e...
Background: The accurate detection of genes and the identification of functional regions is still an...
Genome wide disease association analysis using SNPs is being explored as a method for dissecting com...
We address the problem of comparing and characterizing the promoter regions of genes with similar ex...
Our inability to associate distant regulatory elements with the genes that they regulate has largely...
The laboratory mouse is the most widely used mammalian model organism in biomedical research. The 2....
To understanding the interaction network among transcription-regulation elements in human is an imme...
Our inability to associate distant regulatory elements with the genes that they regulate has largel...
To broaden our understanding of the evolution of gene regulation mechanisms, we generated occupancy ...
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the prem...