The current inability of clinical psychiatry to objectively select the most appropriate treatment is a major factor contributing to the severity and clinical burden of major depressive disorder (MDD). Here, we have attempted to identify plasma protein signatures in 39 MDD patients to predict response over a 6-week treatment period with antidepressants. LC-MS/MS analysis showed that differences in the levels of 29 proteins at baseline were found in the group with a favorable treatment outcome. Most of these proteins were components of metabolism or immune response pathways as well as multiple components of the coagulation cascade. After 6 weeks of treatment, 43 proteins were altered in responders of which 2 (alpha-actinin and nardilysin) had...
Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in...
[No abstract available]767e15e17Fava, G.A., Subclinical symptoms in mood disorders: Pathophysiologic...
Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-econom...
The current inability of clinical psychiatry to objectively select the most appropriate treatment is...
Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent...
Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk fact...
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors ...
Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk fact...
During the past several years, we have achieved a deeper understanding of the etiology/pathophysiolo...
Much has still to be learned about the molecular mechanisms of depression. This study aims to gain i...
Introduction: Millions of people worldwide suffer from depression, but despite advances in pharmacol...
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors ...
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psy...
Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in...
[No abstract available]767e15e17Fava, G.A., Subclinical symptoms in mood disorders: Pathophysiologic...
Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-econom...
The current inability of clinical psychiatry to objectively select the most appropriate treatment is...
Major depressive disorder (MDD) is a leading cause of global disability with a chronic and recurrent...
Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk fact...
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors ...
Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk fact...
During the past several years, we have achieved a deeper understanding of the etiology/pathophysiolo...
Much has still to be learned about the molecular mechanisms of depression. This study aims to gain i...
Introduction: Millions of people worldwide suffer from depression, but despite advances in pharmacol...
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Although genetic factors ...
Despite significant research efforts aimed at understanding the neurobiological underpinnings of psy...
Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in...
[No abstract available]767e15e17Fava, G.A., Subclinical symptoms in mood disorders: Pathophysiologic...
Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-econom...