Add to ORKGHuman mast cell tryptases represent a subfamily of trypsin-like serine proteinases implicated in asthma. Unlike beta-tryptases, alpha-tryptases apparently are proteolytically inactive. We have solved the 2.2 Angstrom crystal structure of mature human alpha1-tryptase. It reveals a frame-like tetrameric architecture that, surprisingly, does not require heparin- binding for stability. In marked contrast to beta2-tryptase, the Ser214-Gly219 segment, which normally provides the template for substrate binding, is kinked in alpha-tryptase, thereby blocking its non-primed subsites. This so far unobserved subsite distortion is incompatible with productive substrate binding and processing. alpha-Tryptase apparently is trapped in this off-conformation...
Human mast cell tryptase (EC 3.4.21.59) is a trypsin-like serine protease that is stored in and rele...
AbstractBackground: Tryptase is a trypsin-like serine proteinase stored in the cytoplasmic granules ...
Human lung mast cell tryptase is a trypsin-like serine proteinase that is stored in mast cell granul...
Human mast cell tryptases represent a subfamily of trypsin-like serine proteinases implicated in ast...
Tryptases are trypsin-like serine proteinases found in the granules of mast cells. Although they sho...
Tryptases are trypsin‐like serine proteinases found in the granules of mast cells. Although they sho...
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory gran...
α- and β-tryptases are trypsin-like serine proteinases that are synthesized in huge amounts by mast ...
The tetrameric protease tryptase, the most abundant protein product of human mast cells, is emerging...
Tryptases are trypsin-like enzymes found in mast cell granules that appear to exist as tetramers. Th...
Tryptases are 31 kDa, glycosylated, trypsin-like enzymes that are stored in and released from mast c...
Tryptase is a 31 kDa, glycosylated, trypsin-like enzyme stored in and released from mast cell granul...
Human lung tryptase (HLT), a trypsin-like serine proteinase stored as an active enzyme in associatio...
The amino acid sequence of human mast cell tryptase was determined from corresponding cDNA cloned fr...
Tryptases are trypsin-like enzymes found in mast cell granules. Although in vivo substrates have not...
Human mast cell tryptase (EC 3.4.21.59) is a trypsin-like serine protease that is stored in and rele...
AbstractBackground: Tryptase is a trypsin-like serine proteinase stored in the cytoplasmic granules ...
Human lung mast cell tryptase is a trypsin-like serine proteinase that is stored in mast cell granul...
Human mast cell tryptases represent a subfamily of trypsin-like serine proteinases implicated in ast...
Tryptases are trypsin-like serine proteinases found in the granules of mast cells. Although they sho...
Tryptases are trypsin‐like serine proteinases found in the granules of mast cells. Although they sho...
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory gran...
α- and β-tryptases are trypsin-like serine proteinases that are synthesized in huge amounts by mast ...
The tetrameric protease tryptase, the most abundant protein product of human mast cells, is emerging...
Tryptases are trypsin-like enzymes found in mast cell granules that appear to exist as tetramers. Th...
Tryptases are 31 kDa, glycosylated, trypsin-like enzymes that are stored in and released from mast c...
Tryptase is a 31 kDa, glycosylated, trypsin-like enzyme stored in and released from mast cell granul...
Human lung tryptase (HLT), a trypsin-like serine proteinase stored as an active enzyme in associatio...
The amino acid sequence of human mast cell tryptase was determined from corresponding cDNA cloned fr...
Tryptases are trypsin-like enzymes found in mast cell granules. Although in vivo substrates have not...
Human mast cell tryptase (EC 3.4.21.59) is a trypsin-like serine protease that is stored in and rele...
AbstractBackground: Tryptase is a trypsin-like serine proteinase stored in the cytoplasmic granules ...
Human lung mast cell tryptase is a trypsin-like serine proteinase that is stored in mast cell granul...