Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma
- Becker, J.
- May, A.
- Gerges, C.
- Anders, M.
- Veits, L.
- Weise, K.
- Czamara, D.
- Lyros, O.
- Manner, H.
- Terheggen, G.
- Venerito, M.
- Noder, T.
- Mayershofer, R.
- Hofer, J.
- Karch, H.
- Ahlbrand, C.
- Arras, M.
- Hofer, S.
- Mangold, E.
- Heilmann-Heimbach, S.
- Heinrichs, S.
- Hess, T.
- Kiesslich, R.
- Izbicki, J.
- Hoelscher, A.
- Bollschweiler, E.
- Malfertheiner, P.
- Lang, H.
- Moehler, M.
- Lorenz, D.
- Müller-Myhsok, B.
- Ott, K.
- Schmidt, T.
- Whiteman, D.
- Vaughan, T.
- Noethen, M.
- Hackelsberger, A.
- Schumacher, B.
- Pech, O.
- Vashist, Y.
- Vieth, M.
- Weismueller, J.
- Neuhaus, H.
- Roesch, T.
- Ell, C.
- Gockel, I.
- Schumacher, J.
DOIAbstract
The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's esophagus. We aimed at further replicating the association at these and other loci that showed suggestive association with P< 10(-4) in the BEACON sample. In total, we tested 88 SNPs in an independent sample consisting of 1065 EAC cases and 1019 controls of German descent. We could replicate the association at FOXP1, BARX1, and FOXF1 wit...
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