Add to ORKGWnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained β-catenin activity in neural crest cells promotes the formation of sensory neural cells in vivo at the expense of virtually all other neural crest derivatives. Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a β-catenin-dependent manner. Thus, the role of Wnt/β-catenin in stem cells is cell-type dependent
Activation of Wnt signaling enhances self-renewal of mouse embryonic and neural stem/progenitor cell...
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs...
In mammals, many diseases of the central nervous system (CNS) are associated with substantial neuron...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
Wnt, a large majority (~80%) of the clones were very small and only formed sensory neurons. This res...
Wnt/β-catenin signaling controls multiple steps of neural crest development, ranging from neural cre...
Activation of Wnt signaling enhances self-renewal of mouse embryonic and neural stem/progenitor cell...
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs...
In mammals, many diseases of the central nervous system (CNS) are associated with substantial neuron...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, ...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells...
β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
β-catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream sign...
Wnt, a large majority (~80%) of the clones were very small and only formed sensory neurons. This res...
Wnt/β-catenin signaling controls multiple steps of neural crest development, ranging from neural cre...
Activation of Wnt signaling enhances self-renewal of mouse embryonic and neural stem/progenitor cell...
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs...
In mammals, many diseases of the central nervous system (CNS) are associated with substantial neuron...