Add to ORKGThe 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation and has a highly conserved structure from slime molds to humans. The elongated molecule which has a molecular mass of approximately 2,000 kD is formed by a barrel-shaped 20S core complex and two polar 19S complexes. The 20S complex has C2 symmetry and is built by four seven-membered rings of which the outer rings are rotated by 26 degrees relative to the inner rings while the inner rings are in register. The 19S cap complex is asymmetric and therefore considerably less well understood on a structural level. From a comparison of the activity and regulation of the 26S and 20S particles, it can be deduced that the 20S particle contains the prot...
The ubiquitin-proteasome system is responsible for the targeted degradation of proteins within the c...
The proteasome is a multisubunit protease complex with an apparent sedimentation coefficient of 20S....
AbstractThe proteasome is a cellular protease responsible for the selective degradation of the major...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
Proteasomes play a key role in the degradation of abnormal proteins, of short-lived regulatory prote...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
The 26S proteasome is a molecular machine of approximately 2.5 MDa, which degrades ubiquitylated pro...
Intracellular proteolysis is an essential process. In eukaryotes, most proteins in the cytosol and n...
<p>The 20S core is a hollow cylindrical structure composed of two heptameric rings of α-subunits and...
The 26S proteasome is a 2.5 MDa molecular machine for the degradation of substrates of the ubiquitin...
In eukaryotes protein degradation is performed by the ubiquitin-proteasome system. The 26S proteasom...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic...
The ubiquitin-proteasome system is responsible for the targeted degradation of proteins within the c...
The proteasome is a multisubunit protease complex with an apparent sedimentation coefficient of 20S....
AbstractThe proteasome is a cellular protease responsible for the selective degradation of the major...
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation...
Proteasomes play a key role in the degradation of abnormal proteins, of short-lived regulatory prote...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteas...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
The 26S proteasome is a molecular machine of approximately 2.5 MDa, which degrades ubiquitylated pro...
Intracellular proteolysis is an essential process. In eukaryotes, most proteins in the cytosol and n...
<p>The 20S core is a hollow cylindrical structure composed of two heptameric rings of α-subunits and...
The 26S proteasome is a 2.5 MDa molecular machine for the degradation of substrates of the ubiquitin...
In eukaryotes protein degradation is performed by the ubiquitin-proteasome system. The 26S proteasom...
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the p...
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic...
The ubiquitin-proteasome system is responsible for the targeted degradation of proteins within the c...
The proteasome is a multisubunit protease complex with an apparent sedimentation coefficient of 20S....
AbstractThe proteasome is a cellular protease responsible for the selective degradation of the major...