S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue, and cardiac S100A1 overexpression in vitro has been shown to enhance myocyte contractile properties. To study the physiological consequences of S100A1 in vivo, transgenic mice were developed with cardiac-restricted overexpression of S100A1. Characterization of two independent transgenic mouse lines with 4-fold overexpression of S100A1 in the myocardium revealed a marked augmentation of in vivo basal cardiac function that remained elevated after -adrenergic receptor stimulation. Contractile function and Ca2+ handling properties were increased in ventricular cardiomyocytes isolated from S100A1 transgenic mice. Enhanced cellular Ca2+ cycling by...
Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function i...
AbstractThe Ca2+ binding protein S100A1 increases the Ca2+ release from the sarcoplasmatic reticulum...
Cardiovascular disease is the leading cause of death worldwide, showing a dramatically growing preva...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue,...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue,...
S100A1, a Ca 2+ binding protein of the EF-hand type, is preferentially expressed in myocardial tissu...
S100A1 is a Ca(2+)-binding protein expressed at high levels in the myocardium. It is thought to modu...
AbstractS100A1, a member of the large EF-hand family of Ca2+-binding proteins, is mainly expressed i...
The Ca2+-binding S100A1 protein displays a specific and high expression level in the human myocardiu...
S100A1, a Ca2-sensing protein of the EF-hand family that is expressed predominantly in cardiac muscl...
S100B, a calcium-binding protein of the EF-hand type, exerts both intracellular and extracellular fu...
Impaired calcium homeostasis and altered expression of Ca2+-binding proteins are associated with car...
AbstractThe Ca2+-binding protein S100A1 displays a tissue-specific expression pattern with highest l...
The effect of S100A1 protein on cardiac excitation-contraction (E-C) coupling was studied using reco...
S100A1 is a Ca(2+)-binding protein and predominantly expressed in the heart. We have generated a mou...
Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function i...
AbstractThe Ca2+ binding protein S100A1 increases the Ca2+ release from the sarcoplasmatic reticulum...
Cardiovascular disease is the leading cause of death worldwide, showing a dramatically growing preva...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue,...
S100A1, a Ca2+-sensing protein of the EF-hand family, is most highly expressed in myocardial tissue,...
S100A1, a Ca 2+ binding protein of the EF-hand type, is preferentially expressed in myocardial tissu...
S100A1 is a Ca(2+)-binding protein expressed at high levels in the myocardium. It is thought to modu...
AbstractS100A1, a member of the large EF-hand family of Ca2+-binding proteins, is mainly expressed i...
The Ca2+-binding S100A1 protein displays a specific and high expression level in the human myocardiu...
S100A1, a Ca2-sensing protein of the EF-hand family that is expressed predominantly in cardiac muscl...
S100B, a calcium-binding protein of the EF-hand type, exerts both intracellular and extracellular fu...
Impaired calcium homeostasis and altered expression of Ca2+-binding proteins are associated with car...
AbstractThe Ca2+-binding protein S100A1 displays a tissue-specific expression pattern with highest l...
The effect of S100A1 protein on cardiac excitation-contraction (E-C) coupling was studied using reco...
S100A1 is a Ca(2+)-binding protein and predominantly expressed in the heart. We have generated a mou...
Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function i...
AbstractThe Ca2+ binding protein S100A1 increases the Ca2+ release from the sarcoplasmatic reticulum...
Cardiovascular disease is the leading cause of death worldwide, showing a dramatically growing preva...