Add to ORKGMutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glut...
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins involved in sca...
Recently, the striatum has been implicated in the spread of epileptic seizures. As the absence of fu...
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been ...
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated...
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated...
AbstractMutant mice lacking the central region of the presynaptic active zone protein Bassoon were g...
SummarySustained rate-coded signals encode many types of sensory modalities. Some sensory synapses p...
Neuronal presynaptic terminals contain hundreds of neurotransmitter-filled synaptic vesicles (SVs). ...
SummaryAt the presynaptic active zone, Ca2+ influx triggers fusion of synaptic vesicles. It is not w...
AbstractThe photoreceptor ribbon synapse is a highly specialized glutamatergic synapse designed for ...
The retinal photoreceptor ribbon synapse is a structurally and functionally unique type of chemical ...
SummaryVoltage-dependent Ca2+ channels (CaVs) represent the principal source of Ca2+ ions that trigg...
The presynaptic active zone contains a complex web of proteins involved in synaptic transmission. In...
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins involved in sca...
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been ...
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins involved in sca...
Recently, the striatum has been implicated in the spread of epileptic seizures. As the absence of fu...
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been ...
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated...
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated...
AbstractMutant mice lacking the central region of the presynaptic active zone protein Bassoon were g...
SummarySustained rate-coded signals encode many types of sensory modalities. Some sensory synapses p...
Neuronal presynaptic terminals contain hundreds of neurotransmitter-filled synaptic vesicles (SVs). ...
SummaryAt the presynaptic active zone, Ca2+ influx triggers fusion of synaptic vesicles. It is not w...
AbstractThe photoreceptor ribbon synapse is a highly specialized glutamatergic synapse designed for ...
The retinal photoreceptor ribbon synapse is a structurally and functionally unique type of chemical ...
SummaryVoltage-dependent Ca2+ channels (CaVs) represent the principal source of Ca2+ ions that trigg...
The presynaptic active zone contains a complex web of proteins involved in synaptic transmission. In...
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins involved in sca...
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been ...
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins involved in sca...
Recently, the striatum has been implicated in the spread of epileptic seizures. As the absence of fu...
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been ...