THE HUMAN ANTIBODY RESPONSE TO DENV2 INFECTION AND VACCINATION

  • Gallichotte, Emily
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Publication date
January 2018
Publisher
University of North Carolina at Chapel Hill Graduate School

Abstract

Dengue viruses (DENVs) are mosquito-borne flaviviruses that are estimated to infect 390 million people each year. Dengue is a major global public health concern because people infected with the virus can develop dengue fever or severe dengue hemorrhagic fever and shock syndrome. Vaccines offer the best hope for controlling the current global DENV pandemic. The major goal of my thesis project was to define the properties of neutralizing and protective human antibodies stimulated by natural DENV infections and the leading live attenuated DENV vaccines. There are four antigenically distinct DENV serotypes, named DENV1 through DENV4. For my studies, I focused on DENV2 as a model to understand human protective immunity following infection...

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