Investigating the binding interaction between human factor XIII and fibrinogen

Venous thrombosis occurs when pathological clotting arises in the venous circulation. Factor XIII (FXIII) crosslinks fibrin, increasing the mechanical stability of clots. FXIII binds to fibrinogen, which accelerates enzymatic activation of FXIII. Recent work implicated FXIII-fibrinogen binding as a determinant of thrombus size. Murine studies suggest that fibrinogen γ-chain residues 390-396, which are highly conserved in human fibrinogen, mediate this binding.Bachelor of Scienc