Unraveling Chemoselectivity in Complex Natural Products Through Parallel Functional Group Studies

The goal of this project is to determine the relative rates of reaction of different chemical functional groups utilizing the catalyst tris(pentafluorophenyl)borane (BCF) along with a tertiary silane (R3SiH) reductant. The focus is on establishing a series of reactivity trends that will allow one to rank the reactivity of diverse functional groups. The insight obtained from these trends will be used to gain predictive powers over more complex structures such as multifunctional drug molecules, all of which compete for reactivity with the catalyst.Bachelor of Scienc