Statement of Purpose: Many chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), are complex and poorly understood. While great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, treatment options remain limited. The dynamic alterations in mechanical properties and composition of the ECM that occur during pathologic tissue remodeling have been extensively studied as a major driver of cellular activation and disease progression. However, current in vitro models of pulmonary tissues rely almost exclusively on naturally derived materials, such as Matrigel, collagen or decellularized ECM (dECM), whic...
In vitro models for investigating mechanisms underlying repair and regeneration in lung disease have...
Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based on MSC secr...
Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor (BMPR2...
Introduction. Idiopathic pulmonary fibrosis is a chronic disease characterized by progressive lung s...
Fibrotic disorders account for over one third of mortalities worldwide. Despite great efforts to stu...
Chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary ...
April KloxinIdiopathic pulmonary fibrosis (IPF) presents a challenge even in this age of advanced me...
Chronic obstructive pulmonary disease (COPD), is a leading cause of death in the United States and i...
Tissue fibrosis remains a serious health condition with high morbidity and mortality rates. There is...
There have been needs for in vitro lung models to rapidly develop new drug or to analyze the associa...
Introduction: Idiopathic Pulmonary Fibrosis (IPF) is characterized by aberrant extracellular matrix ...
Extracellular matrix (ECM) is a dynamic network of proteins, proteoglycans and glycosaminoglycans, p...
Disruption of the complex interplay between cells and extracellular matrix (ECM), the scaffold that ...
Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology with no current curativ...
Decellularization efforts must balance the preservation of the extracellular matrix (ECM) components...
In vitro models for investigating mechanisms underlying repair and regeneration in lung disease have...
Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based on MSC secr...
Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor (BMPR2...
Introduction. Idiopathic pulmonary fibrosis is a chronic disease characterized by progressive lung s...
Fibrotic disorders account for over one third of mortalities worldwide. Despite great efforts to stu...
Chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary ...
April KloxinIdiopathic pulmonary fibrosis (IPF) presents a challenge even in this age of advanced me...
Chronic obstructive pulmonary disease (COPD), is a leading cause of death in the United States and i...
Tissue fibrosis remains a serious health condition with high morbidity and mortality rates. There is...
There have been needs for in vitro lung models to rapidly develop new drug or to analyze the associa...
Introduction: Idiopathic Pulmonary Fibrosis (IPF) is characterized by aberrant extracellular matrix ...
Extracellular matrix (ECM) is a dynamic network of proteins, proteoglycans and glycosaminoglycans, p...
Disruption of the complex interplay between cells and extracellular matrix (ECM), the scaffold that ...
Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology with no current curativ...
Decellularization efforts must balance the preservation of the extracellular matrix (ECM) components...
In vitro models for investigating mechanisms underlying repair and regeneration in lung disease have...
Mesenchymal stromal cell (MSC)-based cell therapy in acute respiratory diseases is based on MSC secr...
Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor (BMPR2...