953-31 Modified Ultrafiltration Reduces Myocardial Edema and Reverses Hemodilution Following Cardiopulmonary Bypass in Children

Cardiopulmonary bypass (CPB) causes a significant increase in total bodywater (TBW) resulting in organ edema and dysfunction. Modified ultrafiltration (MUF) performed following CPB significantly reduces the increase in TBW. The effects of (MUF) on myocardial edema were investigated in 9 children undergoing CPB with cardioplegic arrest for the repair of congenital heart disease. The mean age at the time of surgery was 2.8±3.7 years and the mean weight was 11.4±9.1kg. Five children were under 1 year of age and 5 weighed less than 10kg. The myocardial short axis cross-sectional area (MYOCSA) measured by epicardial echocardiography pre-CPB, post-CPB, and post-MUF was used to assess changes in myocardial wall thickness. The filtrate volume removed by MUF was 470±240mls. The hematocrit (HCT) increased from 24±4% post-CPB to 39±8% following MUF (p<0.0001). MYOCSA increased from 5.6±0.7 to 6.5±0.9 cm2(p=0.011) during CPB. Following MUF, MYOCSA decreased to 5.9±0.8 cm2(p=0.013), which was not significantly different from control (p>0.1). MUF performed following CPB in children reverses hemodilution increasing the HCT and reduces myocardial edema