Structure–activity relationships of some complex I inhibitors

AbstractA wide variety of complex I inhibitors act at or close to the ubiquinone reduction site. Identification of the structural factors required for exhibiting inhibitory actions on the basis of structure–activity relationships is useful to elucidate the manner in which inhibitors interact with the enzyme. This review summarizes studies on the structure–activity relationship of rotenoids, piericidins, capsaicins, pyridinium-type inhibitors and modern synthetic agrochemicals acting at mitochondrial complex I