A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance (Turpin et al., 2014; Raichur et al., 2014)
A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the patho...
There are few and contradictory data on the role of excessive accumulation of intracellular sphingol...
: Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and lo...
Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor α, and glucoco...
SummaryInsulin resistance occurs in 20%–25% of the human population, and the condition is a chief co...
The recent implementation of genomic and lipidomic approaches has produced a large body of evidence ...
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as medi...
Obesity is a major risk factor for a variety of chronic diseases, including diabetes mellitus, and c...
Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipida...
There is a growing amount of data indicating thatceramide is involved in the generation of insulinre...
In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mi...
International audienceInsulin-resistance is a characteristic feature of type 2 diabetes (T2D) and pl...
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance i...
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance i...
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play specialized regula...
A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the patho...
There are few and contradictory data on the role of excessive accumulation of intracellular sphingol...
: Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and lo...
Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor α, and glucoco...
SummaryInsulin resistance occurs in 20%–25% of the human population, and the condition is a chief co...
The recent implementation of genomic and lipidomic approaches has produced a large body of evidence ...
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as medi...
Obesity is a major risk factor for a variety of chronic diseases, including diabetes mellitus, and c...
Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipida...
There is a growing amount of data indicating thatceramide is involved in the generation of insulinre...
In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mi...
International audienceInsulin-resistance is a characteristic feature of type 2 diabetes (T2D) and pl...
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance i...
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance i...
Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play specialized regula...
A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the patho...
There are few and contradictory data on the role of excessive accumulation of intracellular sphingol...
: Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and lo...
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