Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased risk of melanoma. Mutations in NRAS, BRAF, and Tp53 have been described in individual CMN samples; however, their role in the pathogenesis of multiple CMN within the same subject and development of associated features has not been clear. We hypothesized that a single postzygotic mutation in NRAS could be responsible for multiple CMN in the same individual, as well as for melanocytic and nonmelanocytic central nervous system (CNS) lesions. From 15 patients, 55 samples with multiple CMN were sequenced after site-directed mutagenesis and enzymatic digestion of the wild-type allele. Oncogenic missense mutations in codon 61 of NRAS were found in ...
Abstract Background A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infant...
We recently described 17 patients with a new subtype of congenital melanocytic naevi (CMN), designat...
Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived fro...
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased...
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased...
Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise ...
Background: Melanocytic nevi present at birth, or within the first few months of life, are defined a...
Background: Melanocytic nevi present at birth, or within the first few months of life, are defined a...
Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation characterized ...
Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transform...
Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transform...
International audienceCongenital melanocytic nevi (CMN) are benign proliferations that may be associ...
Most melanocytic nevi develop on sun-exposed skin during childhood and adolescence and commonly harb...
We determined mutations in the BRAF, N-ras, and CDKN2A genes in 27 histologically diverse melanocyti...
We report a series of six melanocytic proliferations harboring both NRAS and IDH1 hotspot mutations....
Abstract Background A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infant...
We recently described 17 patients with a new subtype of congenital melanocytic naevi (CMN), designat...
Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived fro...
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased...
Congenital melanocytic nevi (CMN) can be associated with neurological abnormalities and an increased...
Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise ...
Background: Melanocytic nevi present at birth, or within the first few months of life, are defined a...
Background: Melanocytic nevi present at birth, or within the first few months of life, are defined a...
Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation characterized ...
Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transform...
Large congenital melanocytic nevi (CMNs) are said to have a higher propensity to malignant transform...
International audienceCongenital melanocytic nevi (CMN) are benign proliferations that may be associ...
Most melanocytic nevi develop on sun-exposed skin during childhood and adolescence and commonly harb...
We determined mutations in the BRAF, N-ras, and CDKN2A genes in 27 histologically diverse melanocyti...
We report a series of six melanocytic proliferations harboring both NRAS and IDH1 hotspot mutations....
Abstract Background A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infant...
We recently described 17 patients with a new subtype of congenital melanocytic naevi (CMN), designat...
Primary melanocytic neoplasms of the central nervous system (CNS) are uncommon neoplasms derived fro...