Synthesis, spectroscopic characterisation, biological and DNA cleavage properties of complexes of nicotinamide

AbstractTransition metal complexes of nicotinamide with metal precursors such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Cd(II), were synthesized and characterised by physico-chemical and spectroscopic techniques. Based on analytical, spectral and magnetic moments, all the complexes are identified as distorted octahedral in structure. All the complexes are of the ML14L22 type. The shifts of the ν (CN) (azomethine) and ν (CO) (amide) stretches have been monitored in order to find out the donor sites of the ligands. Antibacterial and antifungal activities of the complexes were studied and the complexes were screened against bacteria and fungi. The activity data show that the metal complexes are more potent than the parent nicotinamide