CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy
Immune deficiency disorders are a heterogeneous group of diseases of variable genetic aetiology. Whi...
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutioniz...
Abstract For at least 300 years the immune system has been targeted to improve human health. Decades...
CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to ...
Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on t...
The CTLA-4 checkpoint regulates the activation of T cells. Individuals with heterozygous mutations i...
Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on t...
International audienceKey players on the immunosurveillance program, T cells are regulated by their ...
Gene association studies are very appealing in autoimmune diseases. In recent years, access to other...
Immune system dysfunction is one of the key features in onset and development of cancer and autoimmu...
Heterozygous germline mutations in cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) impair the im...
For at least 300 years the immune system has been targeted to improve human health. Decades of ...
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28...
BACKGROUND: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) i...
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germlin...
Immune deficiency disorders are a heterogeneous group of diseases of variable genetic aetiology. Whi...
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutioniz...
Abstract For at least 300 years the immune system has been targeted to improve human health. Decades...
CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to ...
Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on t...
The CTLA-4 checkpoint regulates the activation of T cells. Individuals with heterozygous mutations i...
Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on t...
International audienceKey players on the immunosurveillance program, T cells are regulated by their ...
Gene association studies are very appealing in autoimmune diseases. In recent years, access to other...
Immune system dysfunction is one of the key features in onset and development of cancer and autoimmu...
Heterozygous germline mutations in cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) impair the im...
For at least 300 years the immune system has been targeted to improve human health. Decades of ...
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28...
BACKGROUND: Heterozygous germline mutations in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) i...
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germlin...
Immune deficiency disorders are a heterogeneous group of diseases of variable genetic aetiology. Whi...
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutioniz...
Abstract For at least 300 years the immune system has been targeted to improve human health. Decades...
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