The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission
SummaryBackgroundSignaling through mitogen-activated protein kinase (MAPK) cascade pathways can show...
BACKGROUND: Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show vari...
SummaryMAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is g...
Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly...
Scaffolding proteins add a new layer of complexity to the dynamics of cell signalling. Above their b...
Scaffold proteins are believed to enhance specificity in cell signaling when different pathways shar...
SummaryThe scaffold protein Ste5 is required to properly direct signaling through the yeast mating p...
AbstractBackground: Signal transduction pathways with shared components must be insulated from each ...
Allosteric interactions provide precise spatiotemporal control over signaling proteins, but how allo...
The MAP kinase cascade is a ubiquitous eukaryotic signaling module that can be controlled by a diver...
Scaffold proteins organize many MAP kinase path-ways by interacting with several components of these...
SummaryAllosteric interactions provide precise spatiotemporal control over signaling proteins, but h...
The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to huma...
Cells reuse signaling proteins in multiple pathways, raising the potential for improper cross talk. ...
To survive, cells must be able to properly sense and respond to information in a fluctuating environ...
SummaryBackgroundSignaling through mitogen-activated protein kinase (MAPK) cascade pathways can show...
BACKGROUND: Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show vari...
SummaryMAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is g...
Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly...
Scaffolding proteins add a new layer of complexity to the dynamics of cell signalling. Above their b...
Scaffold proteins are believed to enhance specificity in cell signaling when different pathways shar...
SummaryThe scaffold protein Ste5 is required to properly direct signaling through the yeast mating p...
AbstractBackground: Signal transduction pathways with shared components must be insulated from each ...
Allosteric interactions provide precise spatiotemporal control over signaling proteins, but how allo...
The MAP kinase cascade is a ubiquitous eukaryotic signaling module that can be controlled by a diver...
Scaffold proteins organize many MAP kinase path-ways by interacting with several components of these...
SummaryAllosteric interactions provide precise spatiotemporal control over signaling proteins, but h...
The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to huma...
Cells reuse signaling proteins in multiple pathways, raising the potential for improper cross talk. ...
To survive, cells must be able to properly sense and respond to information in a fluctuating environ...
SummaryBackgroundSignaling through mitogen-activated protein kinase (MAPK) cascade pathways can show...
BACKGROUND: Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show vari...
SummaryMAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is g...
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