In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key integrator of protein synthesis downstream of the ERK and AKT signaling pathways, providing an intriguing rationale for why their simultaneous targeting could enhance therapeutic efficacy
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
Introduction: The ribosome is a ribonucleoprotein organelle responsible for protein synthesis, and i...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
SummaryPIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors ar...
Ribosomes are ribo-nucleoprotein complexes that read mRNA to synthesize protein during translation. ...
Ribosomes coordinate spatiotemporal control of gene expression, contributing to the acquisition and ...
Elevated protein synthesis is an important feature of many cancer cells and often arises as a conseq...
The ability to translate genetic information into functional proteins is considered a landmark in ev...
The eIF4E translation initiation factor has oncogenic properties and concordantly, the inhibitory eI...
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancie...
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
Ribosomes are nanomachines essential for protein production in all living cells. Ribosome synthesis ...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
Introduction: The ribosome is a ribonucleoprotein organelle responsible for protein synthesis, and i...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
SummaryPIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors ar...
Ribosomes are ribo-nucleoprotein complexes that read mRNA to synthesize protein during translation. ...
Ribosomes coordinate spatiotemporal control of gene expression, contributing to the acquisition and ...
Elevated protein synthesis is an important feature of many cancer cells and often arises as a conseq...
The ability to translate genetic information into functional proteins is considered a landmark in ev...
The eIF4E translation initiation factor has oncogenic properties and concordantly, the inhibitory eI...
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancie...
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
Ribosomes are nanomachines essential for protein production in all living cells. Ribosome synthesis ...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
Introduction: The ribosome is a ribonucleoprotein organelle responsible for protein synthesis, and i...
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