Diagnostic performance of breast MRI with and without the addition of quantitative diffusion weighted imaging

AbstractObjectiveThe purpose of our study was to investigate whether adding diffusion weighted imaging to dynamic contrast-enhanced MRI could improve the diagnostic performance of breast MRI.Materials and methodsThis retrospective study included 86 women with 93 primary and postoperative breast lesions detected on DCE-MRI who underwent subsequent biopsy. The diagnostic performance was calculated for DCE-MRI alone, combined DCE-MRI and quantitative DWI, and for quantitative DWI alone.ResultsOf the 93 lesions, 42 were benign and 51 malignant (5 DCIS, 41 IDC, 2 ILC, 3 NOS). Both DCIS (mean ADC=1.17±0.12×10−3mm2/s) and IDC (mean ADC, 0.98±0.14) exhibited lower mean ADC values than benign lesions (ADC value=1.72±0.36). Applying an ADC cutoff value of 1.33 increased the specificity and PPV of DCE-breast MRI from 59.5% and 75% to 78.5% and 83.3%, respectively. The specificity and PPV for quantitative DW-MRI alone (73.5% and 83.3%) were close to those broken out from the combined use of DCE and quantitative DW-MRI. However, the sensitivity and NPV of DWI remains lower than that of DCE-MRI.ConclusionDWI shows potential for improving the diagnostic performance of breast MRI and may reduce the number of unnecessary biopsies