AbstractA targeted mass spectrometric assay was developed for identification and quantification of apoE isoforms (apoE2, E3 and E4), and it was utilized for screening of samples from AD patients (n=39) and patients with other neurodegenerative disorders (n=38). The assay showed good linearity with LOQ corresponds to total apoE concentration of 0.8 and 40ng/mL in CSF and plasma/serum, respectively. We identified apoE phenotypes with 100% accuracy in clinical samples. We found strong association between genotypes of the individuals and their apoE levels in blood; ϵ4 allele carriers had significantly lower apoE levels in blood than non-carriers
Introduction Alzheimer’s disease (AD) is the major cause of dementia among the elderly. Finding bloo...
Alzheimer’s disease (AD) is the most common type of dementia and, after age, the greatest risk...
Apolipoprotein E (apoE) occurs on the majority of plasma lipoproteins and plays a major role in the ...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's di...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
the development of Alzheimer disease, but data on apoE in cerebrospinal fluid (CSF) are limited. The...
Apolipoprotein E (apoE) is a constitute of several lipoprotein particles with an important role in l...
Apolipoprotein E (ApoE) is a polymorphic protein that plays a major role in lipid metabolism in the ...
Introduction Alzheimer’s disease (AD) is the major cause of dementia among the elderly. Finding bloo...
Alzheimer’s disease (AD) is the most common type of dementia and, after age, the greatest risk...
Apolipoprotein E (apoE) occurs on the majority of plasma lipoproteins and plays a major role in the ...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's di...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
the development of Alzheimer disease, but data on apoE in cerebrospinal fluid (CSF) are limited. The...
Apolipoprotein E (apoE) is a constitute of several lipoprotein particles with an important role in l...
Apolipoprotein E (ApoE) is a polymorphic protein that plays a major role in lipid metabolism in the ...
Introduction Alzheimer’s disease (AD) is the major cause of dementia among the elderly. Finding bloo...
Alzheimer’s disease (AD) is the most common type of dementia and, after age, the greatest risk...
Apolipoprotein E (apoE) occurs on the majority of plasma lipoproteins and plays a major role in the ...