An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessential for proteasome function in most normal tissues, but is overexpressed in many solid tumors
Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and ...
Proteins are the basic building blocks of the human body. Most proteins, after fulfilling their func...
Proteasomes play a critical role in the fate of proteins that are involved in major cellular process...
An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible i...
Degradation rates of most proteins in eukaryotic cells are deter-mined by their rates of ubiquitinat...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting...
Intracellular proteins tagged with ubiquitin chains are targeted to the 26S proteasome for degradati...
The ubiquitin (Ub)-proteasome pathway is the major non-lysosomal pathway of proteolysis in human cel...
Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting differ...
The ubiquitin proteasome pathway is the most significant intracellular proteolytic pathway. The targ...
The proteasome is a validated target in drug discovery for diseases associated with unusual proteaso...
Abstract Proteasomes are multicatalytic protease complexes in the cell, involved in the non-lysosoma...
Rpn13 is a proteasome ubiquitin receptor that has emerged as a therapeutic target for human cancers....
SummaryThe bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RP...
Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and ...
Proteins are the basic building blocks of the human body. Most proteins, after fulfilling their func...
Proteasomes play a critical role in the fate of proteins that are involved in major cellular process...
An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible i...
Degradation rates of most proteins in eukaryotic cells are deter-mined by their rates of ubiquitinat...
The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic system in al...
We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting...
Intracellular proteins tagged with ubiquitin chains are targeted to the 26S proteasome for degradati...
The ubiquitin (Ub)-proteasome pathway is the major non-lysosomal pathway of proteolysis in human cel...
Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting differ...
The ubiquitin proteasome pathway is the most significant intracellular proteolytic pathway. The targ...
The proteasome is a validated target in drug discovery for diseases associated with unusual proteaso...
Abstract Proteasomes are multicatalytic protease complexes in the cell, involved in the non-lysosoma...
Rpn13 is a proteasome ubiquitin receptor that has emerged as a therapeutic target for human cancers....
SummaryThe bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RP...
Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and ...
Proteins are the basic building blocks of the human body. Most proteins, after fulfilling their func...
Proteasomes play a critical role in the fate of proteins that are involved in major cellular process...
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