AbstractThe goal of our study was to evaluate and compare the effects of receptor blockade with different endothelin (ET) receptor antagonists on plasma concentrations of ET-1, big ET-1 and ET-3 in conscious rats. Ro 46-2005 (10 mgkg, i.v.), a novel non-peptide antagonist of both ETA and ETB receptors, increased the concentrations of ET-1 in plasma to 200 ± 13% of basal levels (P < 0.001). This effect was dose- and time-dependent and reached a maximum at 15 min. Ro 46-2005 had no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3. In contrast to Ro 46-2005, the selective peptide ETA antagonists BQ-123 and FR-139317 had no effect on plasma ET-1 concentrations. The increase in plasma ET-1 concentrations by Ro...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Er-i [1-38], big-ET-2[1-37] or big-ET-3[1-41]) injected i.p. in mice have previously been shown to e...
AbstractThe goal of our study was to evaluate and compare the effects of receptor blockade with diff...
ABSTRACT Endothelins (ETs) are 21-amino acid peptides that bind to membrane receptors to initiate pa...
We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the nucleus rap...
Endothelin-1 (1-31) (ET-1 (1-31)) is a novel member of the endothelin family, which comprises 31 ami...
AbstractThe effects of two endothelin (ET) receptor antagonists, PD 155080 (ETA selective) and BQ-78...
Abstract—Endothelin (ET) exerts powerful pressor actions primarily through activation of the ETA rec...
First identified as a powerful vasoconstrictor, endothelin has an extremely diverse set of actions t...
AbstractWe describe here Ro 46-8443, the first non-peptide endothelin ETB receptor selective antagon...
Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertens...
AbstractIn the inhibition of specific binding or [125]endothelins (ETs) to membranes from various ti...
Endothelin-1 (ET-1) is known to cause a transient (1 h) pressor response. The former through the act...
Endothelin-1 (ET-1) predominates in the endothelin family effectively in vascular tone control, mito...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Er-i [1-38], big-ET-2[1-37] or big-ET-3[1-41]) injected i.p. in mice have previously been shown to e...
AbstractThe goal of our study was to evaluate and compare the effects of receptor blockade with diff...
ABSTRACT Endothelins (ETs) are 21-amino acid peptides that bind to membrane receptors to initiate pa...
We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the nucleus rap...
Endothelin-1 (1-31) (ET-1 (1-31)) is a novel member of the endothelin family, which comprises 31 ami...
AbstractThe effects of two endothelin (ET) receptor antagonists, PD 155080 (ETA selective) and BQ-78...
Abstract—Endothelin (ET) exerts powerful pressor actions primarily through activation of the ETA rec...
First identified as a powerful vasoconstrictor, endothelin has an extremely diverse set of actions t...
AbstractWe describe here Ro 46-8443, the first non-peptide endothelin ETB receptor selective antagon...
Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertens...
AbstractIn the inhibition of specific binding or [125]endothelins (ETs) to membranes from various ti...
Endothelin-1 (ET-1) is known to cause a transient (1 h) pressor response. The former through the act...
Endothelin-1 (ET-1) predominates in the endothelin family effectively in vascular tone control, mito...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Endothelin, a 21-amino-acid peptide, binds to a specific receptor on vascular smooth muscle cells, t...
Er-i [1-38], big-ET-2[1-37] or big-ET-3[1-41]) injected i.p. in mice have previously been shown to e...