SummaryNaive and primed pluripotency is characterized by distinct signaling requirements, transcriptomes, and developmental properties, but both cellular states share key transcriptional regulators: Oct4, Sox2, and Nanog. Here, we demonstrate that transition between these two pluripotent states is associated with widespread Oct4 relocalization, mirrored by global rearrangement of enhancer chromatin landscapes. Our genomic and biochemical analyses identified candidate mediators of primed state-specific Oct4 binding, including Otx2 and Zic2/3. Even when differentiation cues are blocked, premature Otx2 overexpression is sufficient to exit the naive state, induce transcription of a substantial subset of primed pluripotency-associated genes, and...
Embryonic stem cells (ESCs) are characterized by their unlimited capacity for self-renewal and the a...
Summary The relationship between chromatin organization and transcriptional regulation is an area of...
SummaryThe relationship between chromatin organization and transcriptional regulation is an area of ...
SummaryNaive and primed pluripotency is characterized by distinct signaling requirements, transcript...
Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of t...
SummaryEmbryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into a...
The core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through transcriptio...
SummaryThe core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through trans...
The enhancer landscape is dramatically restructured as naive preimplantation epiblasts transition to...
Pluripotency factors Oct4, Sox2, and Nanog orchestrate an elaborate hierarchy of gene regulation gov...
SummaryThe enhancer landscape is dramatically restructured as naive preimplantation epiblasts transi...
The transcription factor (TF) Oct4 is essential for maintaining pluripotency in vitro as well as in ...
SummaryMouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naiv...
Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluri...
Much has been learned about the mechanisms of action of pluripotency factors Oct4 and Sox2. However,...
Embryonic stem cells (ESCs) are characterized by their unlimited capacity for self-renewal and the a...
Summary The relationship between chromatin organization and transcriptional regulation is an area of...
SummaryThe relationship between chromatin organization and transcriptional regulation is an area of ...
SummaryNaive and primed pluripotency is characterized by distinct signaling requirements, transcript...
Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of t...
SummaryEmbryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into a...
The core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through transcriptio...
SummaryThe core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through trans...
The enhancer landscape is dramatically restructured as naive preimplantation epiblasts transition to...
Pluripotency factors Oct4, Sox2, and Nanog orchestrate an elaborate hierarchy of gene regulation gov...
SummaryThe enhancer landscape is dramatically restructured as naive preimplantation epiblasts transi...
The transcription factor (TF) Oct4 is essential for maintaining pluripotency in vitro as well as in ...
SummaryMouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naiv...
Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluri...
Much has been learned about the mechanisms of action of pluripotency factors Oct4 and Sox2. However,...
Embryonic stem cells (ESCs) are characterized by their unlimited capacity for self-renewal and the a...
Summary The relationship between chromatin organization and transcriptional regulation is an area of...
SummaryThe relationship between chromatin organization and transcriptional regulation is an area of ...