Tuning Down NF-κB Signaling by DUBs: A Fly Case

The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-κB signaling cassette and shares striking similarities with the mammalian TNF-R1 pathway. Thevenon et al. (2009) reveal how dUSP36, a deubiquitinating enzyme of the ubiquitin-specific protease (USP) family, prevents the constitutive activation of the IMD pathway by resident gut bacteria