AbstractDNA methylation within promoter regions (PRDM) controls vertebrate early gene transcription and thereby development, but is neglected outside this group. However, epigenetic features in the oyster Crassostrea gigas suggest functional significance of PDRM in invertebrates. To investigate this, reporter constructs containing in vitro methylated oyster Hox gene promoters were transfected into oyster embryos. The influence of in vivo methylation was studied using bisulfite sequencing and DNA methyltransferase inhibition during development. Our results demonstrate that methylation controls the transcriptional activity of the promoters investigated, unraveling a functional role for PRDM in a lophotrochozoan, an important finding regarding...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
doi: 10.3389/fphys.2014.00129 Epigenetic features in the oyster Crassostrea gigas suggestive of func...
International audienceIn vertebrates, epigenetic modifications influence gene transcription, and an ...
International audienceIn vertebrates, epigenetic modifications influence gene transcription, and an ...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
Histone methylation patterns are important epigenetic regulators of mammalian development, notably t...
Histone methylation patterns are important epigenetic regulators of mammalian development, notably t...
Abstract Background DNA methylation is an epigenetic mechanism with important regulatory functions i...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
doi: 10.3389/fphys.2014.00129 Epigenetic features in the oyster Crassostrea gigas suggestive of func...
International audienceIn vertebrates, epigenetic modifications influence gene transcription, and an ...
International audienceIn vertebrates, epigenetic modifications influence gene transcription, and an ...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is evolutionarily conserved. Vertebrates exhibit high, widespr...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
International audienceDNA methylation is a critical epigenetic regulator of development in mammals a...
Histone methylation patterns are important epigenetic regulators of mammalian development, notably t...
Histone methylation patterns are important epigenetic regulators of mammalian development, notably t...
Abstract Background DNA methylation is an epigenetic mechanism with important regulatory functions i...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
Thesis (Master's)--University of Washington, 2014Epigenetics describes DNA modifications that change...
doi: 10.3389/fphys.2014.00129 Epigenetic features in the oyster Crassostrea gigas suggestive of func...