AbstractThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separate domains of the α7-subunit of neuronal nicotinic acetylcholine receptor were mutated to phenylalanine, and the electrophysiological response of the resulting mutant receptors analyzed in the Xenopus oocyte expression system. All mutations significantly decreased the apparent affinities for acetylcholine and nicotine, and to a lesser extent, those for the competitive antagonists dihydro-β-erythroidine and α-bungarotoxin. Other properties investigated, such as the voltage dependency of the ion response as well as its sensitivity to the open channel blocker QX222, were not significantly changed, indicating that the mutations affected selectively the recogni...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
International audienceThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separa...
International audienceThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separa...
AbstractThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separate domains of ...
AbstractThe highly conserved αLys145 has been suggested to play an important role in the early steps...
The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and...
Structure-function relations in the nicotinic acetylcholine receptor are probed using a recently dev...
Structure-function relations in the nicotinic acetylcholine receptor are probed using a recently dev...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nicotinic acetylcholine receptor (AChR) is an archetypal neurotransmitter-gated ionic channel. S...
AbstractStandard two electrode voltage clamp techniques were used to investigate the response of neu...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
International audienceThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separa...
International audienceThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separa...
AbstractThree aromatic amino acids, Tyr92, Trp148 and Tyr187 belonging to three separate domains of ...
AbstractThe highly conserved αLys145 has been suggested to play an important role in the early steps...
The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and...
Structure-function relations in the nicotinic acetylcholine receptor are probed using a recently dev...
Structure-function relations in the nicotinic acetylcholine receptor are probed using a recently dev...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nicotinic acetylcholine receptor (AChR) is an archetypal neurotransmitter-gated ionic channel. S...
AbstractStandard two electrode voltage clamp techniques were used to investigate the response of neu...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nonsense codon suppression method for unnatural amino acid incorporation has been applied to int...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...
The nicotinic acetylcholine receptor (nAChR) is involved with regulating the release of neurotransmi...