AbstractThe Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in promoting metastasis, we speculate that these genes might be good targets to block tumour progression without compromising the tumour suppressor effects of the TGFβ pathway
Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes ...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TG...
TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated their epi...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppr...
Transforming growth factor β (TGFβ) plays critical roles in regulating a plethora of physiological p...
Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in maligna...
The objective of this literature-based investigation is to review the current model used to describe...
AbstractThe TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation...
The transforming growth factor-β (TGF- β) is a family of structurally related proteins that comprise...
The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellula...
Even though a cadre of agents that inhibit transforming growth factor β (TGFβ) is being tested in ca...
Abstract Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells...
Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in the regulation of ...
AbstractThe signaling pathway mediated by transforming growth factor-² (TGF-²) participates in vario...
Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes ...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TG...
TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated their epi...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppr...
Transforming growth factor β (TGFβ) plays critical roles in regulating a plethora of physiological p...
Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in maligna...
The objective of this literature-based investigation is to review the current model used to describe...
AbstractThe TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation...
The transforming growth factor-β (TGF- β) is a family of structurally related proteins that comprise...
The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellula...
Even though a cadre of agents that inhibit transforming growth factor β (TGFβ) is being tested in ca...
Abstract Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells...
Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in the regulation of ...
AbstractThe signaling pathway mediated by transforming growth factor-² (TGF-²) participates in vario...
Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes ...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TG...
TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated their epi...