AbstractThe Onecut (OC) transcription factor HNF-6 (OC-1) is required during embryogenesis for pancreatic specification, morphogenesis and endocrine differentiation. In mammals, HNF-6 has two paralogs, OC-2 and OC-3, which share DNA-binding and transcriptional activation properties and have expression patterns that overlap with that of HNF-6. This suggested that OC-2 and OC-3 play redundant roles with HNF-6 in pancreas development. Here, we have addressed this hypothesis by analyzing the phenotype of mice knockout for the Onecut factors. We found that neither OC-2 nor OC-3 is required for pancreas specification. However, OC-2 plays partially redundant roles with HNF-6 in pancreas morphogenesis and in the differentiation of endocrine precurs...
The pancreas is a branched, lobular organ consisting of multiple cell types in two separate tissue c...
The transcription factor Pax6 plays a crucial role for the differentiation of the endocrine cells in...
International audienceHeterozygous mutations in the human HNF1B gene are associated with maturity-on...
The development of the organism involves the formation of tissues that differ by the morphology and ...
Background & Aims: The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of ...
AbstractThe pancreas derives from cells in the ventral and dorsal foregut endoderm that express the ...
The pancreas derives from cells in the ventral and dorsal foregut endoderm that express the transcri...
During development, the endoderm gives rise to several organs, including the pancreas and liver. Thi...
Cell type specification during pancreatic development is tightly controlled by a transcriptional and...
Generation of pancreatic precursor cells in the endoderm is controlled by a network of transcription...
The field of pancreas development has markedly expanded over the last decade, significantly advancin...
The present thesis addresses the role of microRNAs and of the ONECUT factors HNF6 and OC2 in liver a...
Background: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiat...
Transcription factors of the ONECUT class possess a single cut domain and a divergent homeodomain. T...
BACKGROUND & AIMS: A number of hereditary polycystic diseases are associated with formation of cysts...
The pancreas is a branched, lobular organ consisting of multiple cell types in two separate tissue c...
The transcription factor Pax6 plays a crucial role for the differentiation of the endocrine cells in...
International audienceHeterozygous mutations in the human HNF1B gene are associated with maturity-on...
The development of the organism involves the formation of tissues that differ by the morphology and ...
Background & Aims: The Onecut 1 transcription factor (Oc1, a.k.a. HNF6) promotes differentiation of ...
AbstractThe pancreas derives from cells in the ventral and dorsal foregut endoderm that express the ...
The pancreas derives from cells in the ventral and dorsal foregut endoderm that express the transcri...
During development, the endoderm gives rise to several organs, including the pancreas and liver. Thi...
Cell type specification during pancreatic development is tightly controlled by a transcriptional and...
Generation of pancreatic precursor cells in the endoderm is controlled by a network of transcription...
The field of pancreas development has markedly expanded over the last decade, significantly advancin...
The present thesis addresses the role of microRNAs and of the ONECUT factors HNF6 and OC2 in liver a...
Background: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiat...
Transcription factors of the ONECUT class possess a single cut domain and a divergent homeodomain. T...
BACKGROUND & AIMS: A number of hereditary polycystic diseases are associated with formation of cysts...
The pancreas is a branched, lobular organ consisting of multiple cell types in two separate tissue c...
The transcription factor Pax6 plays a crucial role for the differentiation of the endocrine cells in...
International audienceHeterozygous mutations in the human HNF1B gene are associated with maturity-on...