Common Variants of Large Effect in F12, KNG1, and HRG Are Associated with Activated Partial Thromboplastin Time
- Houlihan, Lorna M.
- Davies, Gail
- Tenesa, Albert
- Harris, Sarah E.
- Luciano, Michelle
- Gow, Alan J.
- McGhee, Kevin A.
- Liewald, David C.
- Porteous, David J.
- Starr, John M.
- Lowe, Gordon D.
- Visscher, Peter M.
- Deary, Ian J.
Publication date
April 2010
DOI Publisher
The American Society of Human Genetics. Published by Elsevier Inc.Abstract
Activated partial thromboplastin time (aPTT) is associated with risk of thrombosis and coagulation disorders. We conducted a genome-wide association study for aPTT and identified significant associations with SNPs in three coagulation cascade genes, F12 (rs2731672, combined p = 2.16 × 10−30), KNG1 (rs710446, combined p = 9.52 × 10−22), and HRG (rs9898, combined p = 1.34 × 10−11). These three SNPs explain ∼18% of phenotypic variance in aPTT in the Lothian Birth Cohorts
Add to ORKG