Rapid down-regulation of mitochondrial fat metabolism in human muscle after training cessation is dissociated from changes in insulin sensitivity
- Rimbert, Virginie
- Vidal, Hubert
- Duché, Pascale
- Debard, Cyrille
- Giraudet, Christophe
- Boirie, Yves
- Chardigny, Jean-Michel
- Morio, Béatrice
DOIAbstract
AbstractThe association between impairment in mitochondrial muscle fat oxidative capacity (OXFA) and occurrence of insulin resistance was examined in 14 healthy trained men (age, 24±4yr) submitted to 4weeks of training cessation. Training stop induced a significant decrease in mRNA levels of proteins involved in muscle fat metabolism, particularly PPARα (−58%, P<0.01) and PGC-1α (−30%, P<0.05), a 21% reduction in OXFA (P<0.01), and reduced fat oxidation during moderately intense exercise (P<0.05). In contrast, there was no significant alteration in insulin sensitivity. In conclusion, decline in OXFA is a rapid metabolic event following training cessation. It is involved in the regulation of whole body fat balance but not in the deterioratio...
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