SummaryXylitol dehydrogenase (XDH) is one of several enzymes responsible for assimilating xylose into eukaryotic metabolism and is useful for fermentation of xylose contained in agricultural byproducts to produce ethanol. For efficient xylose utilization at high flux rates, cosubstrates should be recycled between the NAD+-specific XDH and the NADPH-preferring xylose reductase, another enzyme in the pathway. To understand and alter the cosubstrate specificity of XDH, we determined the crystal structure of the Gluconobacter oxydans holoenzyme to 1.9 Å resolution. The structure reveals that NAD+ specificity is largely conferred by Asp38, which interacts with the hydroxyls of the adenosine ribose. Met39 stacked under the purine ring and was als...
Campylobacter jejuni is a pathogenic bacteria that causes gastrointestinal disorders and is thus of ...
The hyperthermophilic archaeon Sulfolobus solfataricus grows optimally above 80 degrees C and utiliz...
In this study, bioengineering was applied to generate enzymes with completely reversed coenzyme spec...
Abstract Xylitol dehydrogenase (XDH) catalyzes the NAD+-dependent oxidization of xylitol into d-xylu...
AbstractAn advanced strategy of Saccharomyces cerevisiae strain development for fermentation of xylo...
Xylitol is a high-value low-calorie sweetener used as sugar substitute in food and pharmaceutical in...
The biosynthesis of value-added products has shown great promise in recent years due to the advances...
An NAD+-dependent xylitol dehydrogenase from A. flavus (AfXDH) was cloned and successfully expressed...
An NAD+-dependent xylitol dehydrogenase (XDH) from Fusarium oxysporum, a key enzyme in the conversio...
BACKGROUND: L-arabitol dehydrogenase (LAD) and xylitol dehydrogenase (XDH) are involved in the degra...
Old Yellow Enzymes (OYEs) are NAD(P)H dehydrogenases of not fully resolved physiological roles that ...
1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is the second enzyme in the non-mevalonate pat...
An NAD +-dependent d-xylose dehydrogenase, XylB, from Caulobacter crescentus was expressed in Saccha...
<div><p>Old Yellow Enzymes (OYEs) are NAD(P)H dehydrogenases of not fully resolved physiological rol...
Abstract Background L-arabitol dehydrogenase (LAD) and xylitol dehydrogenase (XDH) are involved in t...
Campylobacter jejuni is a pathogenic bacteria that causes gastrointestinal disorders and is thus of ...
The hyperthermophilic archaeon Sulfolobus solfataricus grows optimally above 80 degrees C and utiliz...
In this study, bioengineering was applied to generate enzymes with completely reversed coenzyme spec...
Abstract Xylitol dehydrogenase (XDH) catalyzes the NAD+-dependent oxidization of xylitol into d-xylu...
AbstractAn advanced strategy of Saccharomyces cerevisiae strain development for fermentation of xylo...
Xylitol is a high-value low-calorie sweetener used as sugar substitute in food and pharmaceutical in...
The biosynthesis of value-added products has shown great promise in recent years due to the advances...
An NAD+-dependent xylitol dehydrogenase from A. flavus (AfXDH) was cloned and successfully expressed...
An NAD+-dependent xylitol dehydrogenase (XDH) from Fusarium oxysporum, a key enzyme in the conversio...
BACKGROUND: L-arabitol dehydrogenase (LAD) and xylitol dehydrogenase (XDH) are involved in the degra...
Old Yellow Enzymes (OYEs) are NAD(P)H dehydrogenases of not fully resolved physiological roles that ...
1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is the second enzyme in the non-mevalonate pat...
An NAD +-dependent d-xylose dehydrogenase, XylB, from Caulobacter crescentus was expressed in Saccha...
<div><p>Old Yellow Enzymes (OYEs) are NAD(P)H dehydrogenases of not fully resolved physiological rol...
Abstract Background L-arabitol dehydrogenase (LAD) and xylitol dehydrogenase (XDH) are involved in t...
Campylobacter jejuni is a pathogenic bacteria that causes gastrointestinal disorders and is thus of ...
The hyperthermophilic archaeon Sulfolobus solfataricus grows optimally above 80 degrees C and utiliz...
In this study, bioengineering was applied to generate enzymes with completely reversed coenzyme spec...