Ras signaling: PP2A puts Ksr and Raf in the right place

AbstractReversible phosphorylation of proteins, catalysed by protein kinases and phosphatases, is a key mechanism for regulating protein activity. Recent studies reveal a role for protein phosphatase 2A in localisation and activation of two proteins of the Ras–MAPK signaling pathway – Raf-1 and Ksr