Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetochore. Using electron tomography of mammalian cells, McIntosh et al. (2008) now report the presence of fibrils that connect the inner kinetochore to the curved protofilaments at microtubule ends, suggesting a new model for force generation in chromosome movement
SummaryChromosome alignment during mitosis is frequently accompanied by a dynamic switching between ...
AbstractAccurate chromosome segregation is essential to ensure genomic stability because the aneuplo...
The main task of the mitotic spindle is to generate forces that position the chromosomes at the meta...
Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetocho...
Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetocho...
SummaryKinetochores of mitotic chromosomes are coupled to spindle microtubules in ways that allow th...
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, for...
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, for...
Proper segregation of chromosomes during mitosis depends on "amphitelic attachments"-load-bearing co...
During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinet...
Kinetochores link chromosomes to microtubules in the mitotic spindle and generate forces for chromos...
For a cell to divide correctly, the spindle must connect to and align chromosomes and then generate ...
For chromosome segregation in mitosis, each centromere directs assembly of a complex, proteinaceous ...
During mitosis, individual microtubules make attachments to chromosomes via a specialized protein co...
AbstractAnalysis of the interactions between purified motor proteins or isolated chromosomes and shr...
SummaryChromosome alignment during mitosis is frequently accompanied by a dynamic switching between ...
AbstractAccurate chromosome segregation is essential to ensure genomic stability because the aneuplo...
The main task of the mitotic spindle is to generate forces that position the chromosomes at the meta...
Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetocho...
Proper chromosome segregation in mitosis requires tethering of spindle microtubules to the kinetocho...
SummaryKinetochores of mitotic chromosomes are coupled to spindle microtubules in ways that allow th...
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, for...
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, for...
Proper segregation of chromosomes during mitosis depends on "amphitelic attachments"-load-bearing co...
During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinet...
Kinetochores link chromosomes to microtubules in the mitotic spindle and generate forces for chromos...
For a cell to divide correctly, the spindle must connect to and align chromosomes and then generate ...
For chromosome segregation in mitosis, each centromere directs assembly of a complex, proteinaceous ...
During mitosis, individual microtubules make attachments to chromosomes via a specialized protein co...
AbstractAnalysis of the interactions between purified motor proteins or isolated chromosomes and shr...
SummaryChromosome alignment during mitosis is frequently accompanied by a dynamic switching between ...
AbstractAccurate chromosome segregation is essential to ensure genomic stability because the aneuplo...
The main task of the mitotic spindle is to generate forces that position the chromosomes at the meta...