AbstractWe constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow fluorescent protein with the chloride-insensitive cyan fluorescent protein. The ratio of FRET-dependent emission of these fluorophores varied in proportion to the concentration of Cl− and was used to measure intracellular chloride concentration ([Cl−]i) in cultured hippocampal neurons. [Cl−]i decreased during neuronal development, consistent with the shift from excitation to inhibition during maturation of GABAergic synapses. Focal activation of GABAA receptors caused large changes in [Cl−]i that could underlie use-dependent depression of GABA-dependent synaptic transmission. GABA-induced changes in somatic [Cl−]i spread into dendrites...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Intraneuronal chloride concentrations ([Cl- ]i) decrease during development resulting in a shift fro...
We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow f...
We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow f...
AbstractWe constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive ...
International audienceChloride (Cl) is the most abundant physiological anion. Abnormalities in Cl re...
Chloride homeostasis has a pivotal role in controlling neuronal excitability in the adult brain and ...
Neuronal Network consists of two different types of neurons: the excitatory and inhibitory systems. ...
Chloride (Cl-) homeostasis is known to be fundamental for central nervous system functioning. Altera...
Chloride is of eminent relevance for neural signal processing. Its intracellular concentration deter...
BACKGROUND: Regulation of chloride gradients is a major mechanism by which excitability is regulated...
Intracellular chloride and pH are fundamental regulators of neuronal excitability and they are often...
Here we survey a molecular genetic approach for imaging synaptic inhibition. This approach is based ...
Within the nervous system, intracellular Cl- and pH regulate fundamental processes including cell pr...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Intraneuronal chloride concentrations ([Cl- ]i) decrease during development resulting in a shift fro...
We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow f...
We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow f...
AbstractWe constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive ...
International audienceChloride (Cl) is the most abundant physiological anion. Abnormalities in Cl re...
Chloride homeostasis has a pivotal role in controlling neuronal excitability in the adult brain and ...
Neuronal Network consists of two different types of neurons: the excitatory and inhibitory systems. ...
Chloride (Cl-) homeostasis is known to be fundamental for central nervous system functioning. Altera...
Chloride is of eminent relevance for neural signal processing. Its intracellular concentration deter...
BACKGROUND: Regulation of chloride gradients is a major mechanism by which excitability is regulated...
Intracellular chloride and pH are fundamental regulators of neuronal excitability and they are often...
Here we survey a molecular genetic approach for imaging synaptic inhibition. This approach is based ...
Within the nervous system, intracellular Cl- and pH regulate fundamental processes including cell pr...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Chloride is the most abundant physiological anion and participates in a variety of cellular processe...
Intraneuronal chloride concentrations ([Cl- ]i) decrease during development resulting in a shift fro...