AbstractSkin barrier impairment is thought to be an important factor in the pathogenesis of atopic eczema (AE). The skin barrier is located in the stratum corneum (SC), consisting of corneocytes embedded in lipids. Ceramides, cholesterol and free fatty acids are the major lipid classes and are crucial for the skin barrier function, but their role in relation to AE is indistinct. Filaggrin is an epidermal barrier protein and common mutations in the filaggrin gene strongly predispose for AE. However, there is no strong evidence that filaggrin mutations are related to the reduced skin barrier in AE. In this study, electron diffraction is used in order to study the lipid organization of control SC and non-lesional SC of AE patients in vivo. An ...
The barrier function of the skin resides in the stratum corneum (SC), This outermost layer consists ...
BackgroundLoss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk fa...
Background: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk ...
Skin barrier impairment is thought to be an important factor in the pathogenesis of atopic eczema (A...
textabstractA hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corn...
The skin barrier function strongly relies on the outermost layer of the skin, the stratum corneum (S...
Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic...
Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, ha...
Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, ha...
Background: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk ...
The barrier function of the skin resides in the stratum corneum (SC), This outermost layer consists ...
BackgroundLoss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk fa...
Background: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk ...
Skin barrier impairment is thought to be an important factor in the pathogenesis of atopic eczema (A...
textabstractA hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corn...
The skin barrier function strongly relies on the outermost layer of the skin, the stratum corneum (S...
Prior to the discovery of filaggrin (FLG) mutations, evidence for an impaired skin barrier in atopic...
Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, ha...
Mutations in the gene-encoding filaggrin (FLG), a key molecule involved in skin barrier function, ha...
Background: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk ...
The barrier function of the skin resides in the stratum corneum (SC), This outermost layer consists ...
BackgroundLoss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk fa...
Background: Loss-of-function (LOF) mutations in the filaggrin gene (FLG) are a well-replicated risk ...