066 Pulmonary Hypertension and Prognosis of Heart Failure

BackgroundPulmonary hypertension (PH) is common in patients with heart failure (HF) but, its relationship to symptoms and prognosis in a broad representative population of patients with HF has rarely been investigated.MethodsWe interrogated a large database of consecutive referral to a HF clinic serving a population of 600,000 people. Systolic HF (S-HF) was defined as a LVEF≤45% and Preserved systolic LV HF (PS-HF) was defined as LVEF >45% with an NT-proBNP value >400pg/mL. Right Ventricle Systolic Pressure (RVSP) was assessed by the measurement of the tricuspid regurgitation (TR) peak systolic velocity.ResultsOf 2135 patients referred, 1026 had S-HF, 354 had PS-HF and 533 had an accurate TR velocity measurement. Median (IQR) calculated RVSP for HF patients was 25 (18-35mmHg). Amongst these patients, 270 had S-HF and 143 had PS-HF. Mean age, prevalence of ischaemic heart disease and arrhythmia were 74+/-10, 52% and 44%. The maximal follow up was 88 months and the median follow up was 65 months. Amongst 1,380 patients with HF, the 413 with RVSP measurement had a worse prognosis than those who did not (log Rank=0.0001). Patients in the lowest quartile of RVSP (