Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/−) knockout mice
- Shida, Naoki
- Ikeda, Hidetoshi
- Yoshimoto, Takashi
- Oshima, Masanobu
- Taketo, Makoto M.
- Miyoshi, Ichiro
DOIAbstract
AbstractTransforming growth factor (TGF)-β receptor type II gene (Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/−) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/−) mice by estrogen treatment
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