RNA interference holds great promise for antiviral therapy, but delivering effective quantities of small interfering RNAs (siRNAs) into the right target cells in vivo represents a major challenge. Kumar et al. (2008) now report a technique to target siRNAs specifically to T cells to suppress viral infection in a humanized mouse model of HIV/AIDS
International audienceImmunodeficient mice reconstituted with human CD4+ T cells, which can be achie...
Double-stranded RNA can induce gene silencing via a process known as RNA interference (RNAi). Previo...
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small int...
SummaryEvaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the ch...
Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenge...
Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a cons...
RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism in which small interfe...
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in lengt...
HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infe...
Short-term assays have suggested that RNA interference (RNAi) may be a powerful new method for intra...
Short-term assays have suggested that RNA interference (RNAi) may be a powerful new method for intra...
Post-transcriptional inhibition of HIV-1 replication can be achieved by RNA interference (RNAi). The...
HIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universal...
Short hairpin RNAs (shRNA) targeting viral or cellular genes can effectively inhibit human immunodef...
HIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universal...
International audienceImmunodeficient mice reconstituted with human CD4+ T cells, which can be achie...
Double-stranded RNA can induce gene silencing via a process known as RNA interference (RNAi). Previo...
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small int...
SummaryEvaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the ch...
Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenge...
Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a cons...
RNA interference (RNAi) is an evolutionary conserved gene silencing mechanism in which small interfe...
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in lengt...
HIV-1 drug therapies can prevent disease progression but cannot eliminate HIV-1 viruses from an infe...
Short-term assays have suggested that RNA interference (RNAi) may be a powerful new method for intra...
Short-term assays have suggested that RNA interference (RNAi) may be a powerful new method for intra...
Post-transcriptional inhibition of HIV-1 replication can be achieved by RNA interference (RNAi). The...
HIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universal...
Short hairpin RNAs (shRNA) targeting viral or cellular genes can effectively inhibit human immunodef...
HIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universal...
International audienceImmunodeficient mice reconstituted with human CD4+ T cells, which can be achie...
Double-stranded RNA can induce gene silencing via a process known as RNA interference (RNAi). Previo...
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small int...
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