Induction of UCP2 mRNA by thyroid hormones in rat heart
- Lanni, Antonia
- De Felice, Mario
- Lombardi, Assunta
- Moreno, Maria
- Fleury, Christophe
- Ricquier, Daniel
- Goglia, Fernando
Publication date
November 1997
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractThe possible regulation of the expression of uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined in rats. Triiodothyronine (T3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues. The effect of T3 was markedly observed in heart, whereas a moderate effect was seen in skeletal muscle and no effect in kidney or liver. These results suggest that UCP2 is a protein that may be involved in the nuclear-mediated effect of T3 on resting metabolic rate in the rat
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