Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution
SummaryColorectal cancer is one of the major causes of cancer-related deaths. To gain further insigh...
SummaryThe tumor suppressor p53 is a transcription factor that responds to cellular stresses by init...
Abstract Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) ...
Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In th...
SummaryWip1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mech...
IF 5.008International audienceCells undergoing oncogenic transformation frequently inactivate tumor ...
Wild-type (wt) p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase, Mg2+/Mn2+ depen...
Cells in our body respond to genotoxic stress by activation of a conserved DNA damage response pathw...
The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively reg...
When encountering damage, the cells activate the DNA Damage Response (DDR) pathway and stop the cell...
Wild-type p53-induced phosphatase (Wip1 or PPM1D) has been reported to be aberrantly expressed in va...
Abstract Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1...
International audiencePP2C serine-threonine phosphatase, Wip1, is an important regulator of stress r...
PPM1D encodes WIP1, a serine-threonine phosphatase that had previously been shown to be the driver o...
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cance...
SummaryColorectal cancer is one of the major causes of cancer-related deaths. To gain further insigh...
SummaryThe tumor suppressor p53 is a transcription factor that responds to cellular stresses by init...
Abstract Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) ...
Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In th...
SummaryWip1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mech...
IF 5.008International audienceCells undergoing oncogenic transformation frequently inactivate tumor ...
Wild-type (wt) p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase, Mg2+/Mn2+ depen...
Cells in our body respond to genotoxic stress by activation of a conserved DNA damage response pathw...
The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively reg...
When encountering damage, the cells activate the DNA Damage Response (DDR) pathway and stop the cell...
Wild-type p53-induced phosphatase (Wip1 or PPM1D) has been reported to be aberrantly expressed in va...
Abstract Attenuation of p53 activity appears to be a major step in Human T-lymphotropic virus type 1...
International audiencePP2C serine-threonine phosphatase, Wip1, is an important regulator of stress r...
PPM1D encodes WIP1, a serine-threonine phosphatase that had previously been shown to be the driver o...
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cance...
SummaryColorectal cancer is one of the major causes of cancer-related deaths. To gain further insigh...
SummaryThe tumor suppressor p53 is a transcription factor that responds to cellular stresses by init...
Abstract Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) ...
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