AbstractCarbon monoxide is continuously produced in small quantities in tissues and is an important signaling mediator in mammalian cells. We previously demonstrated that CO delivered to isolated rat heart mitochondria using a water-soluble CO-releasing molecule (CORM-3) is able to uncouple mitochondrial respiration. The aim of this study was to explore more in depth the mechanism(s) of this uncoupling effect. We found that acceleration of mitochondrial O2 consumption and decrease in membrane potential induced by CORM-3 were associated with an increase in mitochondrial swelling. This effect was independent of the opening of the mitochondrial transition pore as cyclosporine A was unable to prevent it. Interestingly, removal of phosphate from...
Carbon monoxide (CO) modulates mitochondrial respiration, but the mechanisms involved are not comple...
<div><h3>Aims</h3><p>Metabolic syndrome induces cardiac dysfunction associated with mitochondria abn...
AIMS: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As ...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
Abstract Carbon monoxide (CO), a product of heme degradation by heme oxygenases, plays an important ...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
Carbon monoxide (CO) modulates mitochondrial respiration, but the mechanisms involved are not comple...
<div><h3>Aims</h3><p>Metabolic syndrome induces cardiac dysfunction associated with mitochondria abn...
AIMS: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As ...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide is continuously produced in small quantities in tissues and is...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
International audienceCarbon monoxide (CO), produced during the degradation of heme by the enzyme he...
Abstract Carbon monoxide (CO), a product of heme degradation by heme oxygenases, plays an important ...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
International audienceSeveral studies have reported that CORM-3, a water-soluble carbon monoxide rel...
Carbon monoxide (CO) modulates mitochondrial respiration, but the mechanisms involved are not comple...
<div><h3>Aims</h3><p>Metabolic syndrome induces cardiac dysfunction associated with mitochondria abn...
AIMS: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As ...