Gastric Xanthelasma, Xanthoma, and Xanthomatosis

AbstractBackgroundXanthelasma is a yellowish deposit of cholesterol underneath the skin, usually on or around the eyelids, which is associated with hyperlipidemia. In the stomach, xanthelasma and xanthoma are used interchangeably, and referred to asymtomatic benign endoscopic findings, which are not associated with hyperlipidemia. Gastric xanthomatosis is rare.Patient and methodsWe present the endoscopic and histopathological features of gastric xanthomatosis in a 68-year-old man with a history of peptic ulcer disease and previous antrectomy.ResultsGastric xanthelasma and xanthoma present as solitary white or yellow flat mucosal lesions with fern-like surface features. These discrete lesions are usually found in the antrum. Gastric xanthomatosis presents with multiple small white or yellow mucosal patches or nodules. Histopathologic features include large foamy histiocytes containing a mixture of lipids in the mucosa and submucosa.ConclusionsGastric xanthelasma, xanthoma, gastric xanthomatosis are benign incidental endoscopic findings and are not associated with hyperlipidemia