Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams
- Christian, Akuodor Godwin
- Mfon, Amos Grace
- Dick, Essien Augustine
- David-Oku, Essien
- Linus, Akpan Joseph
- Chukwuma, Ezeokpo Basil
DOIAbstract
AbstractObjectiveTo investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.MethodsThe ethanol extract of A. africana leaf (100–400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.ResultsThe leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).ConclusionsThe findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can...
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